Daoud Meerzaman

Translational research in cancer genomics,, proteo-genomics, precision medicine, and identification of novel molecular targets and treatment.

Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing. Xiao W, Ren L, Chen Z, Fang LT, Zhao Y, Lack J, Guan M, Zhu B, Jaeger E, Kerrigan L, Blomquist TM, Hung T, Sultan M, Idler K, Lu C, Scherer A, Kusko R, Moos M, Xiao C, Sherry ST, Abaan OD, Chen W, Chen X, Nordlund J, Liljedahl U, Maestro R, Polano M, Drabek J, Vojta P, Kõks S, Reimann E, Madala BS, Mercer T, Miller C, Jacob H, Truong T, Moshrefi A, Natarajan A, Granat A, Schroth GP, Kalamegham R, Peters E, Petitjean V, Walton A, Shen TW, Talsania K, Vera CJ, Langenbach K, de Mars M, Hipp JA, Willey JC, Wang J, Shetty J, Kriga Y, Raziuddin A, Tran B, Zheng Y, Yu Y, Cam M, Jailwala P, Nguyen C, Meerzaman D, Chen Q, Yan C, Ernest B, Mehra U, Jensen RV, Jones W, Li JL, Papas BN, Pirooznia M, Chen YC, Seifuddin F, Li Z, Liu X, Resch W, Wang J, Wu L, Yavas G, Miles C, Ning B, Tong W, Mason CE, Donaldson E, Lababidi S, Staudt LM, Tezak Z, Hong H, Wang C, Shi L. Nat Biotechnol. 2021 Sep;39(9):1141-1150. doi: 10.1038/s41587-021-00994-5. Epub 2021 Sep 9. PMID: 34504346 Free PMC article.

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing.  Fang LT, Zhu B, Zhao Y, Chen W, Yang Z, Kerrigan L, Langenbach K, de Mars M, Lu C, Idler K, Jacob H, Zheng Y, Ren L, Yu Y, Jaeger E, Schroth GP, Abaan OD, Talsania K, Lack J, Shen TW, Chen Z, Stanbouly S, Tran B, Shetty J, Kriga Y, Meerzaman D, Nguyen C, Petitjean V, Sultan M, Cam M, Mehta M, Hung T, Peters E, Kalamegham R, Sahraeian SME, Mohiyuddin M, Guo Y, Yao L, Song L, Lam HYK, Drabek J, Vojta P, Maestro R, Gasparotto D, Kõks S, Reimann E, Scherer A, Nordlund J, Liljedahl U, Jensen RV, Pirooznia M, Li Z, Xiao C, Sherry ST, Kusko R, Moos M, Donaldson E, Tezak Z, Ning B, Tong W, Li J, Duerken-Hughes P, Catalanotti C, Maheshwari S, Shuga J, Liang WS, Keats J, Adkins J, Tassone E, Zismann V, McDaniel T, Trent J, Foox J, Butler D, Mason CE, Hong H, Shi L, Wang C, Xiao W; Somatic Mutation Working Group of Sequencing Quality Control Phase II Consortium. Nat Biotechnol. 2021 Sep;39(9):1151-1160. doi: 10.1038/s41587-021-00993-6. Epub 2021 Sep 9. PMID: 34504347 Free PMC article.

TNF plays a crucial role in inflammation by signaling via T cell TNFR2.  Alam MS, Otsuka S, Wong N, Abbasi A, Gaida MM, Fan Y, Meerzaman D, Ashwell JD. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109972118. doi: 10.1073/pnas.2109972118. PMID: 34873037 Free PMC article.

Molecular Profiling of Exceptional Responders to Cancer Therapy.  Bilusic M, Girardi D, Zhou Y, Jung K, Pei J, Slifker M, Chen Q, Meerzaman D, Alpaugh K, Young D, Flieder D, Gray P, Plimack E. Oncologist. 2021 Mar;26(3):186-195. doi: 10.1002/onco.13600. Epub 2020 Nov 28. PMID: 33210795 Free PMC article.

gcMECM: graph clustering of mutual exclusivity of cancer mutations. Hu Y, Yan C, Chen Q, Meerzaman D. BMC Bioinformatics. 2021 Dec 14;22(1):592. doi: 10.1186/s12859-021-04505-w. PMID: 34906079 Free PMC article.

The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis. Cheng D, Semmens K, McManus E, Chen Q, Meerzaman D, Wang X, Hafner M, Lewis BA, Takahashi H, Devaiah BN, Gegonne A, Singer DS. Sci Adv. 2021 Dec 10;7(50):eabi5751. doi: 10.1126/sciadv.abi5751. Epub 2021 Dec 10. PMID: 34890234 Free PMC article.

A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients. Zingone A, Sinha S, Ante M, Nguyen C, Daujotyte D, Bowman ED, Sinha N, Mitchell KA, Chen Q, Yan C, Loher P, Meerzaman D, Ruppin E, Ryan BM. Nat Commun. 2021 Sep 23;12(1):5605. doi: 10.1038/s41467-021-25763-5. PMID: 34556645 Free PMC article.

Molecular Characterization of the Highest Risk Adult Patients With Acute Myeloid Leukemia (AML) Through Multi-Omics Clustering. Nguyen T, Pepper JW, Nguyen C, Fan Y, Hu Y, Chen Q, Yan C, Meerzaman D. Front Genet. 2021 Oct 29;12:777094. doi: 10.3389/fgene.2021.777094. eCollection 2021. PMID: 34777485 Free PMC article.

Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study. Zhao Y, Fang LT, Shen TW, Choudhari S, Talsania K, Chen X, Shetty J, Kriga Y, Tran B, Zhu B, Chen Z, Chen W, Wang C, Jaeger E, Meerzaman D, Lu C, Idler K, Ren L, Zheng Y, Shi L, Petitjean V, Sultan M, Hung T, Peters E, Drabek J, Vojta P, Maestro R, Gasparotto D, Kõks S, Reimann E, Scherer A, Nordlund J, Liljedahl U, Foox J, Mason CE, Xiao C, Hong H, Xiao W. Sci Data. 2021 Nov 9;8(1):296. doi: 10.1038/s41597-021-01077-5. PMID: 34753956 Free PMC article.

Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network. Zeng Z, Fu J, Cibulskis C, Jhaveri A, Gumbs C, Das B, Sanchez-Espiridion B, Janssens S, Taing L, Wang J, Lindsay J, Vilimas T, Zhang J, Tokheim C, Sahu A, Jiang P, Yan C, Duose DY, Cerami E, Chen L, Cohen D, Chen Q, Enos R, Huang X, Lee JJ, Liu Y, Neuberg DS, Nguyen C, Patterson C, Sarkar S, Shukla S, Tang M, Tsuji J, Uduman M, Wang X, Weirather JL, Yu J, Yu J, Zhang J, Zhang J, Meerzaman D, Thurin M, Futreal A, Karlovich C, Gabriel SB, Wistuba II, Liu XS, Wu CJ. Clin Cancer Res. 2021 Sep 15;27(18):5049-5061. doi: 10.1158/1078-0432.CCR-20-3251. Epub 2020 Dec 15. PMID: 33323402 Free PMC article.

Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma. Carlos-Escalante JA, Gómez-Flores-Ramos L, Bian X, Perdomo-Pantoja A, de Andrade KC, Mejía-Pérez SI, Cacho-Díaz B, González-Barrios R, Reynoso-Noverón N, Soto-Reyes E, Sánchez-Correa TE, Guerra-Calderas L, Yan C, Chen Q, Castro-Hernández C, Vidal-Millán S, Taja-Chayeb L, Gutiérrez O, Álvarez-Gómez RM, Gómez-Amador JL, Ostrosky-Wegman P, Mohar-Betancourt A, Herrera-Montalvo LA, Corona T, Meerzaman D, Wegman-Ostrosky T. Cell Mol Neurobiol. 2021 Aug;41(6):1285-1297. doi: 10.1007/s10571-020-00901-7. Epub 2020 Jun 13. PMID: 32535722

B.S. George Washington University

M.S. George Washington University

Doctorate: George Washington University

Fellowships: Children’s National Medical Center in Washington D.C., Joint program at the University of Maryland at Baltimore and Johns Hopkins University