Arnaud Martin

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Arnaud Martin

Associate Professor of Biology



Evolutionary and Developmental genetics of butterflies and Moths


Our team is interested in the genetic and developmental mechanisms underlying pattern formation and structural coloration in butterfly wings.

(*: equal contributions)

Livraghi L, Martin A, Gibbs M, Braak N, Arif S, Breuker CJ. CRISPR/Cas9 as the Key to Unlocking the Secrets of Butterfly Wing Pattern Development and Its Evolution. Advances in Insect Physiology. 2017 Dec. Review

Mazo-Vargas A, Concha C*, Livraghi L*, Massardo D*, Wallbank R*, Zhang L, Papador JD, Martinez- Najera D, Kronforst MR, Breuker CJ, Reed RD, Patel NH, McMillan WO, Martin A. Macro-evolutionary shifts of WntA function potentiate butterfly wing pattern diversity. Proceedings of the National Academy of Sciences USA 2017 Oct; 114(40):10701-10706

Martin A, Courtier-Orgogozo V. Morphological evolution repeatedly caused by mutations in signaling ligand genes. Book Chapter in T. Sekimura, F. Nijhout (eds.), Diversity and Evolution of Butterfly Wing Patterns; Springer Singapore, 2017

Zhang L, Martin A, Perry MW, van der Burg KR, Matsuoka Y, Monteiro A, Reed RD. Genetic Basis of Melanin Pigmentation in Butterfly Wings. Genetics. 2017 Apr; 205(4):1537-1550.

Martin A, Serano JM, Jarvis E, Bruce HS, Wang J, Ray S, Barker CA, O’Connell LC, Patel NH. CRISPR/Cas9 mutagenesis reveals versatile roles of Hox genes in crustacean limb specification and evolution. Current Biology. 2015 Dec; pii: S0960-9822(15)01415-3

Serano JM, Martin A, Liubicich DM, Jarvis E, Bruce HS, La K, Browne WE, Grimwood J, Patel NH. Comprehensive analysis of Hox gene expression in the amphipod crustacean Parhyale hawaiensis. Developmental Biology. 2015 Nov; S0012-1606(15)30166-4

Orgogozo V, Morizot B, Martin A. The differential view of genotype-phenotype relationships. Frontiers in Genetics. 2015 May; 6:179. Review

Huber B, Whibley A, Poul YL, Navarro N, Martin A, Baxter S, Shah A, Gilles B, Wirth T, McMillan WO, Joron M. Conservatism and novelty in the genetic architecture of adaptation in Heliconius butterflies. Heredity. 2015 Mar; 114(5):515-524

Martin A, Reed RD. Wnt signaling underlies evolution and development of butterfly wing pattern symmetry systems. Developmental Biology. 2014 Nov; 395(2):367-78

Gallant JR, Imhoff VE, Martin A, Savage WK, Chamberlain NL, Pote BL, Peterson C, Smith G, Evans B, Reed RD, Kronforst MK, Mullen SP. Ancient homology underlies adaptive mimetic diversity across butterflies. Nature Communications 2014 Sep; 5(4817)

Kunte K*, Zhang W*, Tenger-Trolander A, Palmer D, Martin A, Reed RD, Mullen SP, Kronforst MR. Doublesex is a mimicry supergene. Nature 2014 Mar; 507(7491):229-32

Martin A, McCulloch KJ, Patel NH, Briscoe AD, Gilbert LE, Reed RD. Multiple recent co-options of Optix associated with novel traits in adaptive butterfly wing radiations. EvoDevo 2014 Feb; 5:7

Orgogozo V, Martin A. Evolution and Development: Genes and Mutations underlying Phenotypic Variation. Oxford Bibliographies Online: Evolutionary Biology 2014 Jan; doi: 10.1093/obo/9780199941728-0003. Review

Martin A, Orgogozo V. The loci of repeated evolution: a catalog of genetic hotspots of phenotypic variation. Evolution 2013 May; 67: 1235–1250. Review

Martin A, Papa R, Nadeau NJ, Hill RI, Counterman BA, Halder G, Jiggins CD, Kronforst MR, Long AD, McMillan WO*, Reed RD*. Diversification of complex butterfly wing patterns by repeated regulatory evolution of WntA. Proceedings of the National Academy of Sciences USA. 2012 Jul; 109(31):12632-7

The Heliconius Genome Consortium. A butterfly genome reveals promiscuous exchange of mimicry adaptations among species. Nature. 2012 Jul; 487(7405):94-8

Reed RD*, Papa R*, Martin A, Hines HM, Counterman BA, Pardo-Diaz C, Jiggins CD, Chamberlain NL, Kronforst MR, Chen R, Halder G, Nijhout HF, McMillan WO. optix drives the repeated convergent evolution of butterfly wing pattern mimicry. Science. 2011 Aug; 333:1137-1141

Martin A, Reed RD. wingless and aristaless2 define a developmental ground plan for moth and butterfly wing pattern evolution. Molecular Biology and Evolution. 2010 Dec; 27(12):2864-78

McDonald WP*, Martin A*, Reed RD. Butterfly wings shaped by a molecular cookie cutter: Evolutionary radiation of lepidopteran wing shapes associated with a derived Cut / wingless wing margin boundary system. Evolution and Development. 2010 May; 12:296-304

McGowan L, Kuo E, Martin A, Monuki ES, Striedter G. Species differences in early patterning of the avian brain. Evolution. 2010 Mar ; 65(3):907-11

Pantalacci S, Sémon M, Martin A, Chevret P, Laudet V. Heterochronic shifts explain variations in a sequentially developing repeated pattern: palatal ridges of muroid rodents. Evolution and Development. 2009 Jul-Aug; 11(4):422-33

Pantalacci S, Prochazka J*, Martin A*, Rothova M, Lambert A, Bernard L, Charles C, Viriot L, Peterkova R and Laudet V. Patterning of palatal rugae through sequential addition reveals anterior-posterior boundary in palatal development. BMC Developmental Biology. 2008 Dec ; 8(1):116

Papa R*, Martin A*, Reed RD. Genomic hotspots of adaptation in butterfly wing pattern evolution. Current Opinion in Genetics and Development. 2008 Dec; 18(6):559-64. Review

Chevalier S, Martin A, Leclère L, Amiel A, Houliston E. Polarised expression of FoxB and FoxQ2 genes during development of the hydrozoan Clytia hemisphaerica. Development Genes and Evolution. 2006 Nov; 216(11):709

Assistant Professor, tenure-track, The George Washington University, Department of Biological Sciences, Washington DC, 2016

Post-Doctoral Researcher, University of California – Berkeley (Advisor: Nipam Patel), 2014-2015

Post-Doctoral Researcher, Cornell University/ University of California - Irvine. (advisor: Robert Reed. Host lab and co-advisor: Thomas Schilling), 2012-2014

Ph.D. in Biological Sciences - Evolutionary Genetics group, University of California – Irvine ; Thesis: The developmental genetics of color pattern evolution in butterflies (advisor: Robert Reed), 2007-2012

Master in Molecular and Cellular Biology, Ecole Normale Supérieure de Lyon ; Thesis: Development and diversity of rodent palatal rugae profiles in rodents. (Advisors: Vincent Laudet, Sophie Pantalacci). 2006-2007

License (B.S.) in Molecular and Cellular Biology , Ecole Normale Supérieure de Lyon / Université Lyon I. 2003-2006