Matan Oren

Matan Oren

Postdoctoral Scientist
SEH 5324
[email protected]

Invertebrate immune systems are complex and significantly different from one species to another. My current research is focused on an immune gene family of the California Purple Sea Urchin, Strongylocentrotus purpuratus, known as the Sp185/333. These genes are highly diverse and have a very unique molecular structure which includes a mosaic pattern of short sequence elements and microsatellites that confine it. This unique structure seems to regulate and be regulated by several diversification mechanisms. In order to have a better understanding about these mechanisms, we have sequenced the full gene repertoire of the family and have recorded the expression patterns in single cells following immune challenge. We are also using a modified forensic lab technique to identify exact DNA fragment lengths in a screen for Sp185/333 modifications at the DNA level. The outcomes may reveal novel gene diversification mechanisms and provide important insights about the evolution of immune systems.


Post Doctoral fellow, Bar Ilan University, Ramat Gan. 2011-2012 
Subject: Circadian rhythms in the model cnidarian Nematostella Vectensis 
PI: Dr. Oren Levy

PhD in biology, Tel Aviv University, Tel Aviv. June, 2011 
Dissertation: Morphologic and genetic characterization of allogeneic immune rejection in a tunicate and a coral. 
Advisors: Dr. Baruch Rinkevich and Prof. Zvi Fishelson 

MSc in biology (Cum Laude), Tel Aviv University, Tel Aviv. August, 2004 
Thesis: Aspects of sponge culture for the production of bioactive materials 
Advisors: Dr. Micha Ilan and Shmuel Carmeli

B. A. in business management & geography, Hebrew University, Jerusalem. October, 1998


Oren M, Tarrant A*, Shahar A, Simon-Blecher N, Elbaz I, Appelbaum L, Levy O. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensi. Sci. Rep. 2015. 5 (11418). doi: 10.1038/srep11418 (2015) *Equal contribution

Majeske AJ*Oren M*, Sacchi S, Smith CL. Single sea urchin phagocytes express messages of a single sequence from the diverse Sp185/333 gene family in response to bacterial challenge. J. Immunol. 2014, doi:10.4049. *Equal contribution.

Oren M, Brickner I, Appelbaum L, Oren L. Fast Neurotransmission Related Genes Are Expressed in Non Nervous Endoderm in the Sea Anemone Nematostella vectensisPLoS ONE. 2014. 9(4): e93832.

Oren M, Paz G, Douek J, Amar KO, Rosner A, Rinkevich B. Marine invertebrates cross phyla comparisons reveal highly conserved immune machinery. Immnobiol. 2013. 218: 484-395.

Rinkevich Y, Voskoboynik A, Rosner A, Claudette Rabinowitz, Paz G, Oren M, Douek J, Alfassi G, Moiseeva E, Ishizuka KJ, Palmeri KJ, Weissman IL, Rinkevich B. Repeated, Long-Term Cycling of Putative Stem Cells between Niches in a Basal Chordate. Dev. Cell. 2012. 24(1): 76-88.

Oren M, Paz G, Douek J, Rosner A, Fishelson Z, Goulet TL, Henckel K, Rinkevich B. ‘Rejected’ vs. ‘rejecting’ transcriptomes in allogeneic challenged colonial urochordates. Molecul. Immunol. 2010. 47: 2083-2093.

Oren M, Amar KO, Douek J, Rosenzweig T, Paz G, Rinkevich B. Assembled catalog of immune-related genes from allogeneic challenged corals that unveils the participation of vWF-like transcript. Dev. Comp. Immunol. 2010. 34: 630-637.

Oren M, Escande ML, Paz G, Fishelson Z, Rinkevich B. Urochordate histoincompatible interactions activate vertebrate-like coagulation system components. PLoS ONE. 2008. 3(9): e3123.

Oren M, Douek J, Fishelson Z, Rinkevich B. Identification of immune–relevant genes in histoincompatible rejecting colonies of the tunicate Botryllus schlosseri. Dev. Comp. Immunol. 2007. 31(9): 889-902.

Oren M, Steindler L, Ilan M, Vertical transmission of sponge-associated cyanobacteria. Mar. Biol. 2005. 148: 35-41.

Book Chapters

Oren M,  Hudgell MAB, Golconda P, Man Lun C, Smith CL. Genomic instability and shared mechanisms for gene diversifcationin two distant immune gene families: the echinoid 185/333 and the plant NBS-LRR. Invited book chapter 12, "Evolution of immune systems." 2015.