L. Courtney Smith addt'l Publications

The Sea Urchin Genome 

Rast, JP, LC Smith, M Loza-Coll, T Hibino, GW Litman. 2006. Genomic insights into the immune system of the sea urchin. Science, 314: 952-956. SOM

Sodergren et al. (The Sea Urchin Genome Sequencing Consortium). 2006. The genome of the sea urchin Strongylocentrotus purpuratus. Science, 314: 941-952. Supplemental.

Hibino, T, M Loza-Coll, C Messier, AJ Majeske, AH Cohen, DP Terwilliger, KM Buckley, V Brockton, SV Nair, K Berney, SD Fugmann, MK Anderson, Z Pancer, RA Cameron, LC Smith*, JP Rast*. 2006. The immune gene repertoire encoded in the purple sea urchin genome. Developmental Biology, 300: 349-365. (*contributing authors)

The Sea Urchin Complement System

Terwilliger, DP, LA Clow, PS Gross, LC Smith. 2004. Constitutive expression and alternative splicing of the SCR domains of Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the C2/Bf gene family. Immunogenentics, 56: 531-543.

Clow, LA, DA Raftos, PS Gross, LC Smith. 2004. The sea urchin homologue, SpC3, functions as an opsonin. Journal of Experimental Biology, 207: 2147-2155.

Shah, M, KM Brown, LC Smith. 2003. The gene encoding the sea urchin complement protien, SpC3, is expressed in embryos and can be upregulated by bacteria. Developmental and Comparative Immunology, 27: 529-538.

Smith, LC. 2002. Thioester function is conserved in SpC3, the sea urchin homologue of the complement component C3. Developmental and Comparative Immunology, 26: 603-614.

Clow, LA, PS Gross, C-S Shih & LC Smith. 2000. Expression of SpC3, the sea urchin complement component, in response to lipopolysaccharide. Immunogenetics, 51: 1043-1044.

Gross, PS, LA Clow, LC Smith. 2000. SpC3, the complement homologue from the purple sea urchin, Strongylocentrotus purpuratus, is expressed in two subpopulations of the phagocytic coelomocytes. Immunogenetics, 51: 1021-1033.

Smith, LC, C-S Shih, SG Dachenhausen. 1998. Coelomocytes specifically express SpBf, a homologue of factor B, the second component in the sea urchin complement system. Journal of Immunology, 161: 6784-6793.

Al-Sharif, WZ, JO Sunyer, JD Lambris, LC Smith. 1998. A homologue of the complement component C3 is specifically expressed in sea urchin coelomocytes. Journal of Immunology, 160: 2983-2997.

Sea Urchin ESTs and Other Topics

Stevens, M.E., J. Dhillon, C. Miller, C. Messier-Solek, J.P. Rast, A.J. Majeske, D. Zuelke, L.C. Smith. 2010. SpTie1/2 from the sea urchin Strongylocentrotus purpuratus, is an orthologue of vertebrate Tie1 and Tie2 and is expressed in coelomocytes, axial organ and embryos. Developmental and Comparative Immunology, in press.

Li, C., H-M. Blencke, L.C. Smith, M.T. Karp, K. Stensvag. 2009. Two recombinant peptides, SpStrongylocins 1 and 2, from Strongylocentrotus purpuratus, show antimicrobial activity against Gram-positive and Gram-negative bacteria. Developmental and Comparative Immunology, 34(3): 286-292.

Multerer, KA, LC Smith. 2004. Two cDNAs from the purple sea urchin, Strongylocentrotus purpuratus, encoding mosaic proteins with domains found in factor H, factor I, and complement components C6 and C7. Immunogenetics, 56: 89-106.

Smith, LC, L Chang, RJ Britten, EH Davidson. 1996. Sea urchin genes expressed in activated coelomocytes are identified by expressed sequence tags (ESTs). Complement homologues and other putative immune response genes suggest immune system homology within the deuterostomes. Journal of Immunology, 156: 593-602.

Smith, LC, RJ Britten, EH Davidson. 1995. Lipopolysaccharide activates the sea urchin immune system. Developmental and Comparative Immunology, 19: 217-224.

Smith, LC, MG Harrington, RJ Britten, EH Davidson. 1994. The sea urchin profilin gene is expressed in mesenchyme cells during gastrulation. Developmental Biology, 164: 463-474.

Cameron, R.A., L.C. Smith, R.J. Britten & E.H. Davidson. 1994. Ligand-dependent stimulation of introduced mammalian brain receptors alters spicule symmetry and other morphogenetic events in sea urchin embryos. Mechanisms of Development 45: 31-47.

Smith, LC, RJ Britten, EH Davidson. 1992. SpCoel1, a sea urchin profilin gene expressed specifically in coelomocytes in response to injury. Molecular Biology of the Cell, 3: 403-414

Immune Responses in Marine Sponges

Smith, L.C. & W.H. Hildemann. 1990. Cellular morphology of Callyspongia diffusa (Porifera: Demospongia)In: New Perspectives in Sponge Biology. (K. Ruetzler & W. Hartman, eds.) Smithsonian Institution Press, Washington, D.C., pp. 135-143.

Smith, L.C. 1988. The role of mesohyl cells in sponge allograft rejection. In: Invertebrate Historecognition (R.K. Grosberg, D. Hedgecock & K. Nelson, eds.). Plenum Publishing Co., pp. 15-30.

Smith, L.C. & W.H. Hildemann. 1986. Allogeneic cell interactions during graft rejection in Callyspongia diffusa (Porifera, Demospongia); a study with monoclonal antibodies. Proceedings of the Royal Society of London B 266: 465-477.

Smith, L.C. & W.H. Hildemann. 1986. Allograft rejection, autograft fusion and inflammatory responses to injury in Callyspongia diffusa (Porifera, Demospongia). Proceedings of the Royal Society of London B 266: 445-464.

Smith, L.C. & W.H. Hildemann. 1984. Alloimmune memory is absent in Hymeniacidon sinapium, a marine sponge. Journal of Immunology 135: 2351-2355.